www.RaminSafakish.com
  • Home
  • FAQ
    • video consult
    • Narcotic prescription
    • What kind of pain can be seen in this clinic?
    • Covered by OHIP?
    • Phone consult
    • How to get an appointment?
    • Who I will talk to?
    • Who performs the interventions?
    • Next injection appointment?
  • Video
  • Handouts
  • Services
    • consultation
    • Epidural
    • Facet Joint injection
    • Radiofrequency treatment
    • Stellate Ganglion Block
    • IV Lidocaine infusion
    • Failed back surgery syndrome (FBSS)
    • Lumbar sympathetic Block
    • DGR
  • Contact Us
  • Doctor's corner
    • interesting topics >
      • Diabetic Peripheral Neuropathy
      • Facet generated pain
      • Failed back surgery syndrome (FBSS)
      • TranexAmic Acid in non-Cardiac Surgery
      • increase the duration of nerve block
    • formula of topical cream for pain
  • A. Blog
  • Farsi lecture about End Of Life event
  • contant office - off line
  • Your chance of dying
  • VolunteerNeeded
  • lidocaine study
  • stem cell study
  • new_technique_published
  • testHTML
  • videocall
  • Allevio Research
Clinical Journal of Pain:
September 2012 - Volume 28 - Issue 7 - p 567–572
doi: 10.1097/AJP.0b013e31823b9cc8
Original Articles
Perioperative Intravenous Lidocaine Decreases the Incidence of Persistent Pain After Breast SurgeryGrigoras, Anca MD; Lee, Peter MD; Sattar, Faisal BSc; Shorten, George PhD



Abstract
Objectives: Breast cancer surgery is associated with a high incidence of persistent postsurgical pain (PPSP). The aim of this study was to evaluate the impact of intravenous (IV) lidocaine on acute and PPSP, analgesic requirements, and sensation abnormalities in patients undergoing surgery for breast cancer.

Methods: Thirty-six patients participated in this randomized, double-blinded study. Before induction of general anesthesia, patients received a bolus of intravenous lidocaine 1.5 mg/kg followed by a continuous infusion of lidocaine 1.5 mg/kgh (lidocaine group) or an equal volume of saline (control group). The infusion was stopped 1 hour after the skin closure. Pain scores and analgesic consumption were recorded at 2, 4, 24 hours, and then daily for 1 week postoperatively. Three months later, patients were assessed for PPSP and secondary hyperalgesia.

Results: Two (11.8%) patients in the lidocaine group and 9 (47.4%) patients in the control group reported PPSP at 3 months follow-up (P=0.031). McGill Pain Questionnaire revealed greater present pain intensity-visual analog scale in the control group (14.6±22.5 vs. 2.6±7.5;P=0.025). Secondary hyperalgesia (area of hyperalgesia/length of surgical incision) was significantly less in the lidocaine group compared with control group (0.2±0.8 vs. 3.2±4.5 cm;P=0.002). The 2 groups were similar in terms of analgesic consumption during the early postoperative period.

Discussion: Intravenous perioperative lidocaine decreases the incidence and severity of PPSP after breast cancer surgery. Prevention of the induction of central hyperalgesia is a potential mechanism.


© 2012 Lippincott Williams & Wilkins, Inc.

This is an independent educational website, belongs to Dr. Ramin Safakish, MD.   Copyright & DISCLAIMER

Home

Contact by message

Services

Contact info

  • Home
  • FAQ
    • video consult
    • Narcotic prescription
    • What kind of pain can be seen in this clinic?
    • Covered by OHIP?
    • Phone consult
    • How to get an appointment?
    • Who I will talk to?
    • Who performs the interventions?
    • Next injection appointment?
  • Video
  • Handouts
  • Services
    • consultation
    • Epidural
    • Facet Joint injection
    • Radiofrequency treatment
    • Stellate Ganglion Block
    • IV Lidocaine infusion
    • Failed back surgery syndrome (FBSS)
    • Lumbar sympathetic Block
    • DGR
  • Contact Us
  • Doctor's corner
    • interesting topics >
      • Diabetic Peripheral Neuropathy
      • Facet generated pain
      • Failed back surgery syndrome (FBSS)
      • TranexAmic Acid in non-Cardiac Surgery
      • increase the duration of nerve block
    • formula of topical cream for pain
  • A. Blog
  • Farsi lecture about End Of Life event
  • contant office - off line
  • Your chance of dying
  • VolunteerNeeded
  • lidocaine study
  • stem cell study
  • new_technique_published
  • testHTML
  • videocall
  • Allevio Research